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  9. Air Pollution Modelling And Control
  11. Oxidative Stress Response To Gasoline Generator Exhaust Emission In Adult Male Wistar Rats

Oxidative stress response to gasoline generator exhaust emission in adult male wistar rats

Akinpelu Moronkeji1, Ayodeji Olayanju2, Temidayo Daniel Adeniyi3

  • 1Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Medical Science, Ondo State, Nigeria.

Environmental Analysis, Health and Toxicology
|February 20, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Exposure to gasoline generator exhaust causes oxidative stress in rats, increasing harmful oxidants like MDA and H2O2 while decreasing protective antioxidants such as SOD and GSH. The severity of this stress depends on exposure duration.

Area of Science:

  • Environmental Health
  • Toxicology
  • Biochemistry

Background:

  • Petroleum generators are vital in developing nations but emit harmful pollutants.
  • Generator exhaust poses significant human health risks due to toxic gases and aromatic hydrocarbons.
  • Air pollution from generator emissions is a persistent global health concern.

Purpose of the Study:

  • To investigate the impact of gasoline generator exhaust on oxidative stress markers in adult male Wistar rats.
  • To assess the relationship between exposure duration and the severity of induced oxidative stress.

Main Methods:

  • Forty-eight rats were divided into control and exposed groups (2, 4, 8 hours daily).
  • Lung tissue samples were analyzed for oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and others.
Keywords:
Air pollutionNigeriaRatselectricity

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  • Measurements were taken at 4-week intervals over 12 weeks.

    • Main Results:

    • Exposure to gasoline generator emissions significantly increased oxidant levels (MDA, nitric oxide, hydrogen peroxide).
    • Key antioxidant levels (SOD, GPx, GST, GSH, catalase, TAS) were significantly reduced in exposed rats compared to controls.
    • A dose-dependent relationship was observed, with longer exposure times leading to greater oxidative imbalance.

    Conclusions:

    • Gasoline generator exhaust induces significant oxidative stress in rats.
    • The duration and length of exposure are critical factors determining the extent of oxidative damage.
    • Findings highlight the health risks associated with generator emissions and the need for mitigation strategies.
    health
    oxidative stress