Rationales of Cold Plasma Jet Therapy in Skin Cancer

Area of Science:

• Dermato-oncology
• Plasma medicine

Background:

• Skin cancer incidence is rising globally, necessitating novel therapeutic approaches.
• Current treatments for skin tumors like basal cell carcinoma and melanoma have limitations in effectiveness and tolerability.
• Cold atmospheric plasma (CAP) is an emerging technology with demonstrated safety and efficacy in dermatology.

Purpose of the Study:

• To review the current applications of cold atmospheric plasma in skin cancer treatment.
• To outline the mechanisms of action and treatment concepts for plasma-based therapies in dermato-oncology.
• To explore the integration of CAP into existing skin cancer treatment protocols.

Main Methods:

• Review of existing preclinical and clinical studies on cold atmospheric plasma for skin cancer.
• Focus on approved jet plasma devices and their application in dermato-oncology.
• Analysis of the generation of reactive oxygen and nitrogen species by CAP.

Main Results:

• Cold atmospheric plasma devices have shown safety in clinical trials and are approved for certain dermatological conditions.
• Preclinical and early clinical data suggest significant potential for CAP in treating skin tumors.
• Jet plasma technology is particularly relevant for skin cancer applications.

Conclusions:

• Cold atmospheric plasma presents a viable complementary treatment strategy for skin cancer.
• Further clinical research is crucial to integrate CAP into standard skin cancer care.
• Plasma medicine offers a promising frontier for advancing dermato-oncology.