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Blood rheology and systemic oxidative status in patients with acromegaly

Emine Kilic-Toprak1, Guzin Fidan Yaylali2, Yasin Ozdemir3

  • 1Faculty of Medicine, Department of Physiology, Pamukkale University, Kinikli, Denizli, Turkey.

Biorheology
|February 20, 2025
PubMed

Insights

Acromegaly patients, both active and controlled, exhibit impaired red blood cell (RBC) deformability and increased RBC aggregation. This study highlights hemorheological changes in acromegaly, independent of oxidative stress levels.

Area of Science:

  • Endocrinology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Cardiovascular complications are known in acromegaly.
  • Hemorheological alterations and systemic oxidative status in acromegaly remain under-investigated.

Purpose of the Study:

  • To investigate hemorheology and systemic oxidative stress in acromegaly patients.
  • To assess erythrocyte aggregation and deformability in active and controlled acromegaly.

Main Methods:

  • Erythrocyte aggregation index (AI), aggregation half time (t½), amplitude (Amp), and erythrocyte elongation index (EI) were measured using an ektacytometer.
  • Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were quantified.
  • Study included 19 active acromegaly (AA), 15 controlled acromegaly (CA) patients, and 29 controls.

Main Results:

  • Significant differences in EI and AI were observed across control, AA, and CA groups.
  • Reduced erythrocyte elongation index (EI) indicates decreased deformability.
  • Decreased aggregation half time (t½) correlated with increased AI, suggesting heightened erythrocyte aggregation.
  • Serum TOS, TAS, and OSI levels did not differ significantly among groups.

Conclusions:

  • Acromegaly patients, irrespective of disease control, show reduced erythrocyte deformability.
  • Increased erythrocyte aggregation is a notable hemorheological finding in acromegaly.
  • Systemic oxidative stress markers were not significantly altered in this patient cohort.

Keywords:
Acromegalyantioxidant statuserythrocyte aggregationerythrocyte deformabilityhemorheologyoxidant statusoxidative stress

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