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Updated: Apr 25, 2026
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Electrospinning Fundamentals: Optimizing Solution and Apparatus Parameters
Published on: January 22, 2011
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Electrospinning in Drug Delivery: Progress and Future Outlook
Nurfitrah Halim1, Nithiskanna Nallusamy1, Rajamani Lakshminarayanan2
1Institute of Climate Adaptation and Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, 21030, Malaysia.
Macromolecular Rapid Communications
|February 20, 2025
Summary
Electrospinning technology efficiently produces nanofiber drug delivery systems by adjusting parameters. This review covers system modifications, fiber properties, drug release, medical applications, and future clinical translation challenges.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Electrospinning is a key technique for fabricating nanofiber materials.
- Nanofibers offer unique properties for advanced drug delivery systems.
- Significant research has focused on electrospinning for biomedical applications.
Purpose of the Study:
- To review the role of electrospinning in drug delivery systems.
- To summarize modifications in electrospinning configurations and parameter effects on fiber properties.
- To discuss applications, release mechanisms, and medical uses of electrospun drug carriers.
Main Methods:
- Review of existing literature on electrospinning for drug delivery.
- Analysis of electrospinning system configurations and process parameters.
- Examination of drug loading, release kinetics, and in-vitro/in-vivo studies.
Main Results:
- Electrospinning allows precise control over nanofiber morphology and dimensions.
- Various polymers and drugs can be successfully incorporated into electrospun fibers.
- Electrospun systems demonstrate tunable drug release profiles for diverse medical applications.
Conclusions:
- Electrospinning is a versatile technology for developing innovative drug delivery systems.
- Further research is needed to address challenges in scaling up for clinical applications.
- Optimizing electrospinning processes holds promise for future therapeutic strategies.
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