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Related Concept Videos

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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Diversity in Cell Signaling Responses01:22

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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Stereotypes, Prejudice, and Discrimination02:55

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Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
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Related Experiment Video

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Implementation and Impact of a Diversity Supplement Repository.

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    Institutions can improve diversity supplement applications by implementing a centralized repository and support system. This approach addresses practical barriers, potentially doubling applications and fostering a more diverse biomedical research workforce.

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    Area of Science:

    • Biomedical Research Workforce Diversity
    • Translational Science
    • Research Administration

    Background:

    • National Institutes of Health (NIH) diversity supplements aim to increase workforce diversity.
    • Practical barriers hinder the effective utilization of these valuable resources.
    • The Altman Clinical and Translational Research Institute (ACTRI) at UC San Diego (UCSD) identified a need for improved application support.

    Purpose of the Study:

    • To develop and implement an institutional repository and support system to enhance NIH diversity supplement applications.
    • To overcome practical barriers faced by potential applicants.
    • To create a scalable model for other institutions.

    Main Methods:

    • Established a secure, web-based repository with successful NIH diversity supplement examples.
    • Implemented a matchmaking system connecting applicants with mentors.
    • Provided web-based resources for prospective applicants.
    • Launched the system in June 2021 and tracked access and application data.

    Main Results:

    • The repository contains 51 supplement examples across 14 NIH divisions.
    • Accessed by 51 potential applicants since implementation.
    • Early data indicates a doubling of diversity supplement applications at UCSD compared to the pre-implementation period.
    • Limited uptake of the mentor matchmaking component.

    Conclusions:

    • A centralized repository and support system can effectively address barriers to NIH diversity supplement applications.
    • This model shows promise for increasing applications and contributing to a more diverse biomedical research workforce.
    • Further refinement is needed to address implementation challenges and maximize resource utilization.