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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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Pregnancy Reduces COVID-19 Vaccine Immunity Against Novel Variants

Maclaine A Parish, Jaiprasath Sachithanandham, Lizeth Gutierrez

    Medrxiv : the Preprint Server for Health Sciences
    |February 20, 2025
    PubMed
    Summary

    Pregnancy may weaken immune responses to COVID-19 mRNA booster vaccines, especially against new variants. Pregnant women showed reduced antibody breadth and T cell function compared to non-pregnant individuals.

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