Related Experiment Video

Updated: Jun 27, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

14.0K

Motor evoked potentials as a side effect biomarker for deep brain stimulation programming

Paola Testini, Austin Wang, Eric Cole

    Medrxiv : the Preprint Server for Health Sciences
    |February 20, 2025
    PubMed
    Abstract

    More Related Videos

    Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation11:12

    Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

    Published on: July 16, 2014

    22.2K
    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test07:14

    A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

    Published on: May 31, 2016

    14.6K

    Related Concept Videos

    Long-term Potentiation01:35

    Long-term Potentiation

    Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
    Muscle Contraction01:15

    Muscle Contraction

    Muscle Contraction01:10

    Muscle Contraction

    In skeletal muscles, acetylcholine is released by nerve terminals at the motor endplate—the point of synaptic communication between motor neurons and muscle fibers. The binding of acetylcholine to its receptors on the sarcolemma allows entry of sodium ions into the cell and triggers an action potential in the muscle cell. Thus, electrical signals from the brain are transmitted to the muscle. Subsequently, the enzyme acetylcholinesterase breaks down acetylcholine to prevent excessive muscle...
    Long-term Potentiation01:25

    Long-term Potentiation

    Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
    Hebbian LTP
    LTP can occur when presynaptic neurons...
    Motor Unit Stimulation01:20

    Motor Unit Stimulation

    When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
    The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
    Muscle Stimulation Frequency01:22

    Muscle Stimulation Frequency

    The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
    Wave summation
    At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...