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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Analyzing the correlation between acute ischemic stroke and triglyceride-glucose index based on ordered logistic
1Department of Neurology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
Frontiers in Neurology
|February 20, 2025
Summary
Higher insulin resistance, measured by the triglyceride-glucose (TyG) index, is linked to worse outcomes in acute ischemic stroke patients treated with alteplase. Early intervention for insulin resistance may improve recovery after stroke.
Area of Science:
- Neurology
- Metabolic Syndrome
- Cardiovascular Research
Background:
- Acute ischemic stroke is a leading cause of disability.
- Intravenous alteplase is a standard treatment for acute ischemic stroke.
- Insulin resistance is a growing concern in cardiovascular and neurological health.
Purpose of the Study:
- To investigate the association between insulin resistance, quantified by the triglyceride-glucose (TyG) index, and clinical outcomes.
- To assess the impact of the TyG index on functional recovery in patients receiving alteplase therapy.
Main Methods:
- Retrospective study of 165 acute ischemic stroke patients treated with alteplase.
- Insulin resistance assessed using the TyG index.
- Correlation analysis between TyG index and modified Rankin Scale (mRS) scores at 14, 30, and 90 days post-stroke.
Main Results:
- Each unit increase in the TyG index significantly increased the risk of poor functional outcomes at 14, 30, and 90 days post-stroke.
- Higher TyG index values correlated with worse neurological outcomes.
- While male gender, older age, and smoking showed trends towards poorer outcomes, these did not reach statistical significance.
Conclusions:
- Elevated TyG index, indicating insulin resistance, is a significant predictor of poor neurological outcomes in acute ischemic stroke patients.
- Targeting insulin resistance early may enhance clinical outcomes in stroke patients.
- Further research is warranted to explore additional factors influencing neurological recovery.
Keywords:
acute ischemic strokeinsulin resistanceintravenous thrombolysismodified Rankin scaletriglyceride-glucose indexMore Related Videos
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