Water-Resistant, Scalable, and Inexpensive Chiral Metal-Organic Framework Featuring Global Negative Electrostatic...

Physical separation of acetylene (C₂H₂) from carbon dioxide (CO₂) or ethylene (C₂H₄) on metal-organic frameworks (MOFs) is crucial for achieving high-purity feed gases with minimal energy penalty. However, such processes are exceptionally challenging due to their close physical properties and are also critically restricted by the high cost of large-scale MOF synthesis. Here, we demonstrate the readily scalable synthesis of a highly water-resistant chiral Cu-MOF (TAMOF-1) based on an inexpensive proteogenic amino acid derivative bearing rich N/O sites. Notably, the unique coordination in this ultramicroporous MOF has resulted in the generation of rare global negative electrostatic potentials, which greatly facilitate the electrostatic interactions with C₂H₂ molecules, thus leading to their efficient separation from C₂H₂/CO₂ and C₂H₂/C₂H₄ mixtures under ambient conditions. The separation efficiency and mechanism are unequivocally validated by breakthrough experiments and computational simulations. This work not only highlights the pivotal role of creating a negative electro-environment in confined spaces for boosting C₂H₂ capture and separation but also opens up new ways of employing cheap amino acid derivatives bearing rich electro-negative N and O sites as organic linkers to constructing high-performing MOF materials for gas separation purposes.