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Related Experiment Videos

Digoxin treatment and control in the elderly.

M Sonnenblick, A S Abraham

    Israel Journal of Medical Sciences
    |March 1, 1985
    PubMed
    Summary

    Long-term digoxin therapy in elderly patients showed poor correlation between serum levels and clinical status. Optimal dosing appears to be 0.19 mg daily, suggesting careful monitoring is crucial for effective and safe treatment.

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    Area of Science:

    • Geriatric Medicine
    • Clinical Pharmacology
    • Cardiology

    Background:

    • Digoxin is commonly prescribed for elderly patients.
    • Long-term use necessitates understanding efficacy and toxicity risks.
    • Elderly populations may have altered pharmacokinetics, affecting drug response.

    Purpose of the Study:

    • To assess the efficacy and toxicity of long-term digoxin therapy in elderly patients.
    • To determine the correlation between serum digoxin levels and clinical outcomes.
    • To identify optimal digoxin dosage in this demographic.

    Main Methods:

    • Retrospective analysis of 81 elderly patients receiving long-term digoxin.
    • Correlation of serum digoxin levels with clinical status and electrocardiographic findings.
    • Evaluation of prescribed dosages against therapeutic ranges.

    Main Results:

    • Serum digoxin levels did not correlate with clinical state.
    • Only 47% of patients had effective serum digoxin levels; 38% were below therapeutic range.
    • 17% showed electrocardiographic evidence of digoxin toxicity; 51% received pediatric doses.

    Conclusions:

    • Routine serum digoxin monitoring did not improve management in this cohort.
    • The optimal digoxin dosage for non-renal failure, non-underweight elderly patients appears to be 0.19 mg/day.
    • Careful dosage adjustment and monitoring are essential for digoxin therapy in the elderly.

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