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Progressive brain atrophy during normal aging in man: a quantitative computerized tomography study.

I Steiner, J M Gomori, E Melamed

    Israel Journal of Medical Sciences
    |March 1, 1985
    PubMed
    Summary
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    Normal aging causes brain mass loss, affecting both central and cortical areas. This brain atrophy begins in young adulthood and progresses with age, as shown by computerized tomogram (CT) scans.

    Area of Science:

    • Neuroimaging
    • Gerontology
    • Human Anatomy

    Background:

    • Brain aging is a complex process impacting cognitive function.
    • Understanding normative brain volume changes is crucial for diagnosing neurological disorders.
    • Previous studies have indicated age-related brain volume reduction, but detailed quantitative data across a wide age range are needed.

    Purpose of the Study:

    • To quantitatively assess the impact of normal aging on brain mass integrity.
    • To establish normative measurements of brain volume parameters in a healthy adult population.
    • To determine the age of onset and progression of age-related brain atrophy.

    Main Methods:

    • Quantitative analysis of computerized tomograms (CT) from 148 neurologically intact subjects.

    Related Experiment Videos

  • Measurement of ten key brain volume indices, including ventricular size, fissure width, and cistern dimensions.
  • Age range of subjects: 28 to 84 years.

    • Main Results:

    • Advancing age is significantly associated with a progressive loss of brain substance.
    • Brain atrophy occurs in both cortical and central regions.
    • Evidence suggests that brain atrophy begins at a younger age than previously assumed, not solely in older populations.

    Conclusions:

    • Normal aging leads to measurable and progressive brain volume reduction.
    • Brain atrophy is a widespread phenomenon affecting both central and cortical structures.
    • The established normative data can serve as a valuable reference for comparative studies in neurological conditions.