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Bioavailability of phenytoin: comparison between three preparations.
Israel Journal of Medical Sciences
|April 1, 1985
Summary
This study found that three phenytoin preparations (DANTOIN, IDANTOIN, and EPANUTIN) show equivalent absorption in healthy volunteers. Therefore, switching between these phenytoin formulations does not require dose adjustments.
Area of Science:
- Pharmacokinetics
- Drug bioavailability studies
Background:
- Phenytoin is an anticonvulsant medication.
- Different phenytoin preparations exist, with varying bioavailability claims.
- DANTOIN recently replaced IDANTOIN in Israel due to alleged superior bioavailability.
Purpose of the Study:
- To compare the bioavailability of three oral phenytoin preparations: DANTOIN, IDANTOIN, and EPANUTIN.
- To determine if absorption differences necessitate adjustments when switching between formulations.
Main Methods:
- A crossover study design was employed.
- Single oral doses of each phenytoin preparation were administered.
- 19 healthy volunteers participated in the study.
- Serum concentrations were measured over 48 hours to calculate the area under the curve (AUC).
Main Results:
- No significant differences were observed in the area under the serum concentration time curve (AUC0-48) among the three phenytoin preparations.
- This indicates equivalent absorption of DANTOIN, IDANTOIN, and EPANUTIN.
Conclusions:
- The bioavailability of DANTOIN, IDANTOIN, and EPANUTIN is comparable.
- Patients can switch between these phenytoin preparations without requiring overall dose adjustments.