Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

31.3K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
31.3K
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

24.4K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
24.4K
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

5.3K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.3K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

129
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
129

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combination of single-molecule Förster resonance energy transfer and hydrogen-deuterium exchange mass spectrometry toward dynamic structural biology.

Current opinion in structural biology·2026
Same author

Theory of chromosome structural dynamics by processive loop extrusion.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

20 Years of the ISCB Student Council Symposium: shaping computational biology and future leaders.

Bioinformatics advances·2026
Same author

Statistics of thermal avalanches in driven amorphous systems.

The Journal of chemical physics·2026
Same author

Aggregation of Huntingtin Exon 1 Proteins at Flat and Curved Membrane Surfaces.

The journal of physical chemistry. B·2026
Same author

Probing the dark energy in the functional protein universe.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: May 6, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.6K

Frustration In Physiology And Molecular Medicine.

R Gonzalo Parra1, Elizabeth A Komives2, Peter G Wolynes3

  • 1Life Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain.

Arxiv
|February 20, 2025
PubMed
Summary

Protein local frustration, unresolved interactions in protein structures, is crucial for cellular functions and disease. Understanding this

More Related Videos

Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments
12:34

Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments

Published on: September 16, 2016

7.6K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
00:06

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.6K

Related Experiment Videos

Last Updated: May 6, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.6K
Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments
12:34

Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments

Published on: September 16, 2016

7.6K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
00:06

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

13.6K

Area of Science:

  • Biochemistry and Molecular Biology
  • Structural Biology
  • Systems Biology

Background:

  • Proteins are dynamic molecules essential for cellular functions, operating through complex interaction networks.
  • Protein structures arise from polypeptide chain folding to minimize energetic conflicts among amino acids.
  • Local frustration, residual unresolved interactions in folded proteins, is increasingly recognized as functionally significant.

Purpose of the Study:

  • To review the physical origins and physiological importance of local frustration in proteins.
  • To explore the role of local frustration in protein interactions, catalysis, and allostery.
  • To examine the link between altered frustration patterns and pathologies, and its impact on higher-order systems.

Main Methods:

  • Review of physical principles underlying protein frustration.
  • Analysis of experimental and computational evidence for local frustration's role.
  • Case studies linking frustration alterations to disease and system-level functions.

Main Results:

  • Local frustration is a fundamental property of protein structures, not merely an artifact.
  • This frustration is integral to protein physiology, mediating recognition, catalysis, and allosteric regulation.
  • Changes in local frustration patterns are associated with various pathologies and influence complex biological networks.

Conclusions:

  • Local frustration is a key determinant of protein function and dysfunction.
  • Understanding protein frustration offers insights into molecular mechanisms of health and disease.
  • The concept of frustration extends to understanding complex biological systems like gene regulatory and neural networks.