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Predictive and prognostic markers
Dynamics of blood microsatellite instability (bMSI) burden predicts outcome of a patient treated with immune checkpoint inhibitors: a case report of hyperprogressive disease

Dynamics of blood microsatellite instability (bMSI) burden predicts outcome of a patient treated with immune checkpoint inhibitors: a case report of hyperprogressive disease

Daria Kravchuk ¹, Alexandra Lebedeva ^2,3, Olesya Kuznetsova ^2,4, Alexandra Kavun ², Anastasiia Taraskina ², Ekaterina Belova ^2,3,5, Tatiana Grigoreva ^2,3, Egor Veselovsky ², Vladislav Mileyko ^2,3, Vladislav Nikulin ⁴, Lidia Nekrasova ⁶, Alexey Tryakin ⁴, Mikhail Fedyanin ^1,4,7, Maxim Ivanov ^2,3

Daria Kravchuk ¹, Alexandra Lebedeva ^2,3, Olesya Kuznetsova ^2,4

¹Moscow Multidisciplinary Clinical Center "Kommunarka" of the Department of Health of the City of Moscow, State Budgetary Institution of Healthcare, Moscow, Russia.
²R&D Department, OncoAtlas LLC, Moscow, Russia.
³Institute for Personalized Oncology, Sechenov First Moscow State Medical University, Moscow, Russia.
⁴N.N. Blokhin Russian Cancer Research Center, Moscow, Russia.
⁵Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia.
⁶P. Hertsen Moscow Oncology Research Institute (MORI), Moscow, Russia.
⁷Federal State Budgetary Institution "National Medical and Surgical Center named after N.I. Pirogov" of the Ministry of Health of the Russian Federation, Moscow, Russia.

⁰Moscow Multidisciplinary Clinical Center "Kommunarka" of the Department of Health of the City of Moscow, State Budgetary Institution of Healthcare, Moscow, Russia.

Frontiers in Immunology +

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February 20, 2025

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February 20, 2025

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View abstract on PubMed

Summary

This summary is machine-generated.

Microsatellite instability (MSI) in liquid biopsies can track colorectal cancer (CRC) treatment response. An increase in blood MSI (bMSI) correlated with disease progression during immunotherapy.

Area Of Science

Oncology
Molecular Biology
Genetics

Background

Microsatellite instability (MSI) is a key biomarker for predicting response to immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC).
Liquid biopsies offer a non-invasive method to monitor tumor dynamics during therapy.

Keywords:

colorectal cancer dMMR hyperprogression liquid biopsy next-generation sequencing

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