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Updated: May 27, 2025

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
Is type 2 diabetes a link between lung function and metabolic dysfunction-associated steatotic liver disease?
Runmin Cao1, Yurun Zhang2, Ling Cao3
1Graduate School, Jinzhou Medical University (Jinzhou Central Hospital), Jinzhou, Liaoning Province.
Aim:
This study aimed to investigate the relationship between lung function and metabolic dysfunction-associated steatotic liver disease (MASLD), and the potential mediating role of type 2 diabetes.
Methods:
Data from the 2007 to 2012 National Health and Nutrition Examination Survey were used. Logistic regression analysis was employed to assess the association between lung function parameters [forced vital capacity (FVC), forced expiratory volume in 1 s (FEV 1 ), FEV 1 /FVC] and MASLD prevalence while exploring type 2 diabetes mediation. Further analyses included linkage disequilibrium score regression, Mendelian randomization, and meta-analysis to examine the causal relationship between lung function and MASLD, considering type 2 diabetes mediation.
Results:
The results showed that higher FVC and FEV 1 levels were associated with decreased MASLD risk, with type 2 diabetes partially mediating this relationship. Genetic analyses supported a causal link between lung function and MASLD, with type 2 diabetes acting as an intermediary. However, no significant association was found between FEV 1 /FVC and MASLD.
Conclusion:
The study identified a causal relationship between lung function and MASLD, with type 2 diabetes playing a partial mediating role.
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