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Updated: May 27, 2025

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
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MicroRNA-Mediated Regulation of Cancer Stem Cells: Implications for Radioresistance and Chemoresistance in Cancer

Vasanth Kanth Thasma Loganathbabu1, Harin N Ganesh1, Ravi Gor1

  • 1Department of Genetic Engineering, School of Bio-Engineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, 603203, Tamil Nadu, India.

Microrna (Shariqah, United Arab Emirates)
|February 20, 2025
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression in cancer stem cells (CSCs), influencing treatment resistance. Understanding miRNA roles in CSCs and signaling pathways offers therapeutic targets for overcoming cancer therapy resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression in cancer cells and cancer stem cells (CSCs).
  • Dysregulated miRNAs in CSCs significantly impact cancer progression and resistance to therapies like radiotherapy and chemotherapy.
  • miRNAs influence critical signaling pathways (e.g., Notch, Wnt) affecting CSC behavior and treatment response.

Purpose of the Study:

  • To elucidate the role of microRNAs (miRNAs) in cancer stem cell (CSC) biology and their contribution to therapeutic resistance.
  • To explore the regulatory functions of miRNAs in CSCs and their impact on key signaling pathways.
  • To identify potential therapeutic strategies targeting miRNAs for improved cancer treatment outcomes.

Main Methods:

  • Review and synthesis of existing literature on miRNA function in cancer stem cells.
  • Analysis of miRNA involvement in gene expression regulation within CSCs.
  • Examination of miRNA interactions with signaling pathways like Notch and Wnt.

Main Results:

  • miRNAs are crucial in modulating CSC characteristics and mediating resistance to chemotherapy and radiotherapy.
  • Dysregulation of specific miRNAs affects CSC behavior and survival.
  • miRNA networks interact with major cellular pathways, influencing treatment efficacy.

Conclusions:

  • miRNAs represent promising therapeutic targets for controlling CSCs and enhancing cancer treatment effectiveness.
  • Understanding the interplay between miRNA production, tumor microenvironment, and cell communication is vital for developing novel anti-cancer strategies.
  • Targeting miRNAs can potentially overcome resistance to chemotherapy and radiation in cancer therapy.
Keywords:
MicroRNAcancer stem cellschemoresistance.radioresistance

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