Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

857
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
857
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

1.3K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.3K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

701
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
701
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

601
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
601
Exercise Stress Test01:26

Exercise Stress Test

152
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
152
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.1K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myasthenia Gravis and Thymoma.

Muscle & nerve·2026
Same author

Analysis of infections and malignancy risks among patients with myasthenia gravis compared with matched controls in a US real-world setting.

Journal of neuromuscular diseases·2026
Same author

Survival Outcomes of Medicare-Covered Elderly US Population With Myasthenia Gravis.

Muscle & nerve·2025
Same author

Reply to the Letter to the Editor: The Role of Patient-Reported Symptoms in Standardizing MGFA Class 0 and MGFA-PIS.

Muscle & nerve·2025
Same author

Sensitivity of Repetitive Nerve Stimulation Performed in Early and Later Stages of Myasthenia Gravis.

Muscle & nerve·2025
Same author

Gender Gap or Data Gap? How the AANEM Measures Up in Supporting Women.

Muscle & nerve·2025
Same journal

Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.

Muscle & nerve·2026
Same journal

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications.

Muscle & nerve·2026
Same journal

Reply to "Sural/Radial Amplitude Ratio in Non-Length-Dependent Neuropathy (NLDN): A Call for More Standardized Methodology and Further Evaluation of Distal NLDN".

Muscle & nerve·2026
Same journal

Late-Onset Myasthenia Gravis: An Increasingly Frequent Clinical Entity With Distinctive Challenges.

Muscle & nerve·2026
Same journal

Clinical Characteristics and Treatment Management of Seronegative Myasthenia Gravis: A Systematic Review of the Literature.

Muscle & nerve·2026
Same journal

Muscle-Specific Kinase Signaling and Its Therapeutic Potential.

Muscle & nerve·2026
See all related articles

Related Experiment Video

Updated: May 27, 2025

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

39.9K

Update on Exercise in Persons With Muscle Disease.

Mansoureh Mamarabadi1, Virginia Kudritzki2,3, Yuebing Li4

  • 1Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Muscle & Nerve
|February 20, 2025
PubMed
Summary
This summary is machine-generated.

Exercise interventions, including aerobic and strength training, are generally safe and beneficial for improving muscle strength and function in various myopathies. Personalized exercise plans are recommended as part of routine care for myopathy patients.

Keywords:
exerciseexercise trainingmuscular diseasemuscular dystrophiesresistance training

More Related Videos

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

20.1K
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

16.7K

Related Experiment Videos

Last Updated: May 27, 2025

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

39.9K
Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

20.1K
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

16.7K

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Physiology

Background:

  • Myopathies present diverse symptoms like muscle weakness, atrophy, and pain, impacting daily activities and social participation.
  • Exercise is recognized as a potential intervention to mitigate muscle function loss and alleviate secondary symptoms such as pain and fatigue.

Purpose of the Study:

  • To review research from the past decade on the effects of exercise interventions across various human myopathies.
  • To synthesize findings on the efficacy and safety of different exercise modalities in managing myopathy.

Main Methods:

  • Systematic review of studies published within the last 10 years.
  • Analysis of research examining exercise interventions in diverse myopathy types.
  • Inclusion of studies with varying exercise types, intensities, and outcome measures.

Main Results:

  • Despite study heterogeneity, aerobic/endurance and strength/resistance training generally show benefits for muscle strength and functional outcomes.
  • Exercise therapies are typically safe and well-tolerated by individuals with myopathies.
  • Small-scale studies characterize much of the existing research.

Conclusions:

  • Exercise prescription should be integrated into standard neuromuscular care for myopathy patients, ideally with multidisciplinary input and individualized regimens.
  • Further research is needed to optimize exercise type and intensity for maximum functional benefit and to explore combined approaches with novel therapies.