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Bocavirus Infection as a Potential Trigger for Hepatic Injury in Children

Bera Enes Seyrek1, Kubra Aykac2, İncinur Saltık Temizel3

  • 1Hacettepe University School of Medicine, Ankara, Türkiye.

Journal of Viral Hepatitis
|February 20, 2025
PubMed

Insights

Human Bocavirus (HBoV) may cause liver problems in children, even leading to severe outcomes like liver failure. Further research is needed to confirm this link and guide treatment for pediatric HBoV infections.

Area of Science:

  • Pediatric Gastroenterology and Hepatology
  • Virology and Infectious Diseases

Background:

  • Human Bocavirus (HBoV) is an emerging viral pathogen.
  • HBoV is primarily associated with respiratory and gastrointestinal infections in children.
  • The role of HBoV in pediatric liver dysfunction is not well-established.

Purpose of the Study:

  • To investigate the potential association between Human Bocavirus infection and liver dysfunction in children.
  • To describe clinical presentations and outcomes of pediatric cases with HBoV and elevated liver enzymes or acute liver failure.

Main Methods:

  • Retrospective case series analysis of six pediatric patients.
  • Clinical data review including liver function tests, viral detection, and co-infections.
  • Documentation of patient outcomes, including need for liver transplantation and mortality.

Main Results:

  • Six pediatric cases presented with elevated liver enzymes or acute liver failure during HBoV infection.
  • Severe outcomes observed included liver transplantation and one fatality.
  • Co-infections with other pathogens were common, complicating clinical management.

Conclusions:

  • Human Bocavirus infection may be associated with significant liver injury in children.
  • While direct causality is not proven, the findings suggest HBoV as a potential contributor to pediatric liver dysfunction.
  • Further research is warranted to elucidate the mechanisms and clinical implications of HBoV-associated liver injury.

Keywords:
bocavirushepatitispediatrics

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