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Lymphocyte subsets predict mortality in acute paraquat poisoning
Qian Dong1, Huan Xu1, Pengjie Xu1
1Department of Nephrology, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Biomolecules & Biomedicine
|February 20, 2025
Summary
Acute paraquat (PQ) poisoning significantly impacts lymphocyte subsets. Lower natural killer (NK) cell percentages and altered T cell ratios are linked to increased mortality risk in PQ poisoning patients.
Area of Science:
- Toxicology
- Immunology
- Clinical Medicine
Background:
- Paraquat (PQ) is a potent herbicide with high toxicity, causing acute lung injury (ALI) and death.
- The specific effects of PQ poisoning on lymphocyte subsets and their correlation with mortality remain largely uncharacterized.
Purpose of the Study:
- To investigate the relationship between lymphocyte subset alterations and mortality in patients with acute paraquat poisoning.
- To identify potential predictive biomarkers for mortality in paraquat poisoning.
Main Methods:
- A cohort of 92 paraquat poisoning patients was analyzed.
- Peripheral blood lymphocyte subsets were quantified using flow cytometry.
- COX regression and LASSO models identified independent risk factors for 90-day mortality.
Main Results:
- Patients who died had significantly higher white blood cell and neutrophil counts, lymphocyte counts, and CD4+/CD8+ T cell ratios compared to survivors.
- A significantly lower percentage of natural killer (NK) cells was observed in the non-surviving group.
- Lymphocyte count, neutrophil count, CD4+/CD8+ T cell ratio, and NK cell percentage were identified as independent predictors of mortality.
Conclusions:
- Lymphocyte count, neutrophil count, CD4+/CD8+ T cell ratio, and NK cell percentage are significantly associated with mortality in acute paraquat poisoning.
- These immune parameters may serve as valuable indicators for assessing prognosis in paraquat poisoning cases.
