Unveiling the potential bacteriophage therapy: a systematic review

Area of Science:

• Microbiology
• Infectious Diseases
• Therapeutics

Background:

• Antimicrobial resistance necessitates novel therapeutic strategies.
• Bacteriophages offer a targeted approach against multi-drug-resistant bacteria.

Purpose of the Study:

• To review clinical studies on bacteriophage therapy for bacterial infections.
• To evaluate the safety and efficacy of phage therapy.

Main Methods:

• A systematic literature search identified 11 clinical trials.
• Studies were assessed using the Joann-Briggs-Institute checklist and PRISMA criteria.
• Data on safety, efficacy, and outcomes were extracted and analyzed.

Main Results:

• Phage therapy demonstrated a strong safety profile with minimal side effects across various administration routes.
• Clinical studies confirmed its efficacy in reducing bacterial load, resolving infections, and eradicating biofilms.
• Variability in trial designs limited the generalizability of findings.

Conclusions:

• Phage therapy is a promising, safe, and effective treatment for bacterial infections.
• Gaps in clinical application, long-term efficacy assessment, and trial standardization require addressing.
• Standardization is crucial for establishing phage therapy as a viable alternative for multidrug-resistant infections.