Recent Advancements in the Cyclization Strategies of 1,3-Enynes Towards the Synthesis of Heterocyclic/Carbocyclic
Akash P Sakla1, Shams Aaghaz1, Shujauddin Ahmed2
1National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.
Abstract:
1,3-Enynes have demonstrated their utility as valuable precursors to furnish a diverse range of heterocycles and carbocycles. Their unique structural characteristics enable a new toolbox to introduce requisite complexity in the molecular framework. Cyclization reaction is usually a simple and straightforward way to afford complex organic frameworks. Herein, we collated versatile cyclization strategies that have been developed by employing 1,3-enynes for the synthesis of heterocyclic and carbocyclic scaffolds. Divergent synthesis and mechanistic perspectives to define stereo-, regio- and chemo-selective outcomes of such reactions have also been highlighted.
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