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Detection of Total Reactive Oxygen Species in Adherent Cells by 2',7'-Dichlorodihydrofluorescein Diacetate Staining
Published on: June 23, 2020
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Cellular uptake mechanisms of a diselenide-based ROS-responsive nanocarrier in oxidatively stressed colon cells
Wanqi Liang1, Dong Li2, Jinheng Hao1
1Department of Biology, College of Science, Shantou University, Shantou 515063, Guangdong, China. qiongqiongyang@stu.edu.cn.
Abstract:
Here, we demonstrate that a diselenide-based ROS-responsive nanocarrier exhibits a highly sensitive response to ROS and excellent ROS scavenging activity. Mechanism studies indicate that it can be efficiently taken up by oxidatively stressed colon cells through folate receptor-mediated endocytosis, underscoring its potential for targeted drug delivery in treating colon diseases.

