Use of proteases for animal feed supplementation: scientific and technological updates

The global market is rapidly evolving, with biotechnological advances supporting production centers through innovative techniques. A key focus is on bioprocesses for extracting, purifying, and applying proteases, particularly in animal feed within the agricultural sector. Although the cost reduction may vary depending on the animal species, supplementation with proteases allows for the formulation of more cost-effective diets, improving nutrient digestibility and absorption, optimizing energy efficiency, preserving intestinal integrity, enhancing carcass quality, modulating the intestinal microbiome, and reducing nitrogen excretion. This study aimed to update on protease use in monogastric animal feed, drawing from digital databases (Science Direct, Google Scholar, and Scielo) and industrial property databases (INPI). Despite the significant potential of proteases in monogastric animal nutrition, there is a lack of studies, especially on patented technologies. While their benefits are recognized, substantial investments are needed to develop new technologies and identify alternative protease sources. These advancements could enhance animal performance and strengthen Brazil's productive sector, highlighting the need for further research and innovation. The literature review showed promising results, but research is mainly focused on microbial proteases for poultry, pigs, and fish. There is significant potential to explore diverse protease production sources and their application across various species.