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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: May 27, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Bio-inspired, programmable biomacromolecules based nanostructures driven cancer therapy.

Rahul Sharma1, Unnati Modi1, Rahul Kumar2

  • 1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gujarat 382355, India.

Biomaterials Advances
|February 20, 2025
PubMed
Summary

Bioinspired nanocarriers offer a biocompatible and biodegradable alternative for targeted cancer drug delivery, overcoming limitations of synthetic materials. This review explores their properties, applications, and future potential in cancer therapy.

Keywords:
Bio-inspired nanocarriersCancer therapyDrug delivery

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Oncology

Background:

  • Cancer poses a significant global health challenge, necessitating advanced drug delivery systems.
  • Traditional synthetic nanocarriers often exhibit poor biocompatibility and biodegradability.
  • Bioinspired nanocarriers, derived from natural biomacromolecules, offer improved biocompatibility, biodegradability, and non-toxicity.

Purpose of the Study:

  • To review the properties, advantages, and limitations of various bioinspired nanocarriers for cancer therapy.
  • To explore cutting-edge cancer treatment approaches utilizing these nanocarriers.
  • To discuss challenges and future directions in the field of bioinspired drug delivery.

Main Methods:

  • Literature review of bioinspired nanocarriers (protein-based, lipid-based, carbohydrate-based, nucleic acid-based).
  • Analysis of factors influencing nanocarrier effectiveness (size, shape, surface properties, morphology, functionalization, preparation).
  • Examination of in-vitro, in-vivo, and patent evidence for cancer therapy applications.

Main Results:

  • Bioinspired nanocarriers demonstrate significant potential for targeted and efficient drug delivery in cancer therapy.
  • Different types of bioinspired nanocarriers exhibit unique properties suitable for specific therapeutic strategies.
  • Recent evidence supports the efficacy of these systems in preclinical and clinical settings.

Conclusions:

  • Bioinspired nanocarriers represent a promising advancement in cancer drug delivery, addressing limitations of synthetic alternatives.
  • Further research and development are needed to overcome challenges and fully realize their therapeutic potential.
  • Nature-inspired drug delivery systems are paving the way for innovative cancer treatments.