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Antibiotic Selection

Antibiotic Selection

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Related Experiment Video

Updated: May 2, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

A genetic toolbox for engineering C. acnes.

¹Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.

|February 20, 2025

Summary

This study presents a new genetic toolbox for Cutibacterium acnes, a common skin bacterium. This toolset will advance research and bioengineering applications targeting this hair follicle microbe.

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Last Updated: May 2, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

Engineering Adherent Bacteria by Creating a Single Synthetic Curli Operon

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Published on: November 16, 2012

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

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Published on: January 25, 2019

Area of Science:

Microbiology
Synthetic Biology
Bioengineering

Background:

Cutibacterium acnes is a prevalent skin bacterium residing deep within hair follicles.
Its unique location makes it an attractive target for host-associated research and therapeutic interventions.

Purpose of the Study:

To develop and introduce a comprehensive genetic toolbox for Cutibacterium acnes.
To facilitate future basic science research and bioengineering efforts involving this bacterium.

Main Methods:

Development of a genetic engineering toolkit tailored for Cutibacterium acnes.
Validation of the toolbox components for genetic manipulation.

Main Results:

Successful establishment of a functional genetic toolbox for Cutibacterium acnes.
Demonstration of the toolbox's utility for future research.

Conclusions:

The developed genetic toolbox significantly enhances the capacity for genetic engineering of Cutibacterium acnes.
This resource will accelerate advancements in both fundamental understanding and therapeutic applications related to C. acnes.