Genetic markers of early response to lurasidone in acute schizophrenia
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View abstract on PubMed
Summary
This summary is machine-generated.This study explored genetic biomarkers for early lurasidone treatment response in psychosis. Key genes involved in neurogenesis showed potential associations with treatment effectiveness within the first four weeks.
Area Of Science
- Pharmacogenetics
- Neuroscience
- Psychiatry
Background
- Genetic biomarkers can predict treatment response and elucidate drug mechanisms.
- Early prediction of response to antipsychotics like lurasidone is clinically valuable.
Purpose Of The Study
- To identify genetic biomarkers associated with early response to lurasidone treatment.
- To explore the role of neurogenesis in antipsychotic response.
Main Methods
- Analysis of genetic associations with treatment response in 171 acutely psychotic patients from lurasidone clinical trials.
- Genotyping using Affymetrix 6.0 microarray and association analysis with PLINK regression.
- Examination of genetic markers at weeks one, two, and four using the Positive and Negative Syndrome Scale.
Main Results
- Potential genetic markers associated with early lurasidone response were identified, though genome-wide significance was not reached.
- A marker near the sonic hedgehog gene (SHH), crucial for neurogenesis, was linked to week one response.
- A single nucleotide polymorphism (SNP) in GABRB1 and a SNP within PTCH1 (SHH receptor) were associated with weeks two and four response, respectively.
- Pathway and tissue enrichment analyses suggested the involvement of neurogenesis and the anterior cingulate cortex in early antipsychotic response.
Conclusions
- This study provides preliminary evidence for genetic biomarkers related to very early lurasidone response.
- Genes involved in neurogenesis may play a role in the initial response to lurasidone.
- Larger replication studies are needed to validate these findings.
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