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Updated: May 27, 2025

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Actin-dependent α-catenin oligomerization contributes to adherens junction assembly

Regina B Troyanovsky1, Indrajyoti Indra1, Sergey M Troyanovsky2,3

  • 1Department of Dermatology, Northwestern University, The Feinberg School of Medicine, Chicago, IL, 60611, USA.

Nature Communications
|February 20, 2025
PubMed
Summary

The actin-binding domain of α-catenin forms linear cadherin-catenin complex/actin strands. These strands integrate with E-cadherin clusters, stabilizing cell-cell adhesions and linking them to actomyosin forces.

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