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Association between gallbladder disease and colorectal neoplasia: a meta-analysis

  • 0Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, 68 Gehu middle road, Wujing District, Changzhou, 213000, Jiangsu Province, China.
Scientific Reports +

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February 20, 2025

|

February 20, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Gallbladder disease, including gallstones and polyps, significantly elevates the risk of colorectal neoplasia (CRN). Early screening via colonoscopy is recommended for patients with gallbladder conditions, particularly those of Asian descent or with large polyps.

Area Of Science

  • Gastroenterology
  • Oncology
  • Epidemiology

Background

  • The association between gallbladder disease and colorectal neoplasia (CRN) risk remains debated.
  • Existing studies present conflicting evidence regarding this relationship.

Purpose Of The Study

  • To conduct a comprehensive meta-analysis evaluating the correlation between gallbladder diseases and the risk of developing CRN.
  • To identify specific gallbladder pathologies and demographic factors influencing this risk.

Main Methods

  • A systematic literature search was performed using PubMed and Web of Science, supplemented by manual reference reviews, up to June 2024.
  • Twenty eligible studies were included in the meta-analysis.
  • Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, with subgroup analyses and sensitivity analyses performed to assess heterogeneity and robustness.

Main Results

  • Gallbladder disease was found to significantly increase the risk of CRN (OR = 1.20, 95% CI: 1.11-1.29).
  • Specific conditions like gallstones (OR = 1.14, 95% CI: 1.05-1.25) and gallbladder polyps (OR = 1.23, 95% CI: 1.15-1.31) were associated with higher CRN risk.
  • Asian individuals with gallstones showed an elevated risk (OR = 1.21, 95% CI: 1.11-1.31), and larger gallbladder polyps (≥0.5 cm) posed a greater risk (OR = 1.96, 95% CI: 1.41-2.73).

Conclusions

  • Gallbladder polyps and gallstones are significant risk factors for colorectal neoplasia.
  • Colonoscopic screening is advised for individuals with gallbladder disease, especially those of Asian ethnicity or with large gallbladder polyps, to facilitate early detection and management.

Keywords:

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