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Comparing different viral strains in identifying risk factors for the development of venous thromboembolism in

Harsimran Panesar1,2, Ruchi Raval1, Amber W Chan1

  • 1Hackensack Meridian School of Medicine, Nutley, NJ, USA.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|February 21, 2025
PubMed

Insights

Men, older age, and prior deep vein thrombosis (DVT) history predict DVT risk in hospitalized COVID-19 patients. DVT prevalence remained consistent across COVID-19 waves, unaffected by vaccination status or traditional lab values.

Area of Science:

  • Medical Research
  • Epidemiology
  • Thrombosis

Background:

  • The COVID-19 pandemic caused significant mortality and widespread vaccination efforts.
  • Deep vein thrombosis (DVT) is a serious complication in hospitalized COVID-19 patients.
  • Understanding risk factors for DVT is crucial for patient management.

Purpose of the Study:

  • To identify patient demographics and laboratory values predicting DVT in hospitalized COVID-19 patients.
  • To analyze risk factors across different COVID-19 waves and vaccination periods in the US.
  • To inform risk stratification and management algorithms for COVID-19-associated DVT.

Main Methods:

  • Retrospective cohort study of 4429 COVID-19 patients admitted between March 2020 and February 2024.
  • Analysis of venous duplex ultrasound findings in patients with clinical suspicion of DVT.
  • Evaluation of demographic data, medical history, and laboratory values for predictive significance.

Main Results:

  • Male sex, older age, prior DVT history, and longer length of stay (LOS) to first duplex were prognostic for DVT formation.
  • Active chemotherapy, higher weight, and longer LOS to first duplex predicted mortality.
  • DVT prevalence did not differ significantly across COVID-19 waves; vaccination status and traditional labs were non-predictive.

Conclusions:

  • Specific demographic factors and LOS predict DVT risk in hospitalized COVID-19 patients.
  • DVT incidence remained stable throughout the pandemic, irrespective of vaccination status.
  • Further research can guide anticoagulant and corticosteroid use in this population.

Keywords:
AZCOVID-19 variantsDVT formationScottsdaleearly disease diagnosisoral presentation at the 51st Society of Clinical Vascular Surgery Annual Symposium

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