Renal fibrosis: research progress on mechanisms and therapeutic strategies

Area of Science:

• Nephrology
• Pathology
• Molecular Biology

Background:

• Renal fibrosis (RF) is a common pathway in chronic kidney diseases, leading to end-stage renal disease.
• Multiple mechanisms contribute to RF, including aberrant signaling pathways, microRNAs, aging, and autophagy dysfunction.
• Understanding these mechanisms is crucial for developing effective treatments.

Purpose of the Study:

• To explore recent advancements in understanding the mechanisms of renal fibrosis.
• To review novel therapeutic approaches targeting the identified mechanisms of RF.
• To provide a comprehensive overview of RF pathogenesis and treatment strategies.

Main Methods:

• Literature review of recent studies on renal fibrosis mechanisms.
• Analysis of research on therapeutic interventions targeting signaling pathways, microRNAs, aging, and autophagy.
• Synthesis of information on fibrotic ecological niches and their role in RF.

Main Results:

• Identified key molecular and cellular mechanisms driving renal fibrosis.
• Highlighted the potential of targeting specific pathways (e.g., signaling, microRNAs) for RF treatment.
• Discussed the role of aging and autophagy disorders in fibrotic processes.

Conclusions:

• Targeting the diverse mechanisms of renal fibrosis presents promising therapeutic avenues.
• Further research into inhibiting or delaying RF development is essential for clinical application.
• Comprehensive understanding of RF pathogenesis is key to novel treatment development.