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Emulgel-Based Formulations of Clobetasol Propionate: Formulation Development, Characterization, and Pharmacological
Kuldeep Singh1, Jeetendra Kumar Gupta1, Divya Jain2
1Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.
None:
Topical formulations of corticosteroids, particularly clobetasol propionate (CP), are commonly used to treat a range of dermatological conditions. CP is a potent corticosteroid known for its efficacy in managing inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Emulgel-based formulations of CP have emerged as an innovative approach, offering advantages like improved drug solubility, enhanced skin penetration, and extended drug release. This review aims to provide an updated overview of the latest advancements in the development and evaluation of CP emulgel formulations. Key aspects discussed include the selection and optimization of emulgel components, formulation characterization, in vitro drug release, and pharmacological activities such as anti-inflammatory and anti-pruritic effects. Emphasis is placed on recent studies and innovations that underscore the potential of CP emulgels in dermatological therapy, highlighting their promising applications in enhancing therapeutic efficacy and patient outcomes.
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