Daily fluid intake and brain amyloid deposition: A cohort study

Area of Science:

• Neuroscience
• Neurology
• Gerontology

Background:

• Limited data exists on the link between daily water intake and Alzheimer's disease (AD) pathology.
• Investigating modifiable lifestyle factors like hydration is crucial for AD prevention strategies.

Purpose of the Study:

• To explore the association between daily fluid intake and in vivo AD pathologies (amyloid-beta and tau).
• To examine the correlation between daily fluid intake and cerebrovascular injury in cognitively normal older adults.

Main Methods:

• 287 cognitively normal older adults underwent clinical assessments and daily fluid intake evaluations.
• Multimodal brain imaging was used to assess amyloid-beta and tau deposition and cerebrovascular injury.
• Data was collected at baseline and a 2-year follow-up.

Main Results:

• Low daily fluid intake correlated with higher amyloid-beta (Aβ) deposition, particularly in non-APOE4 individuals.
• Reduced fluid intake was associated with increased cerebrovascular injury.
• A trend towards increased tau pathology was observed with lower fluid intake.

Conclusions:

• High daily fluid intake is linked to reduced brain amyloid deposition.
• Sufficient hydration may be a beneficial strategy for Alzheimer's disease prevention.
• Further research is warranted to confirm these findings and explore mechanisms.