Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optical Spectral Transmission Imaging in Patients with Osteoarthritis: A Comparative Study with Joint Ultrasound and Clinical Markers.

Rheumatology and therapy·2026
Same author

Carotid-femoral pulse wave velocity improves cardiovascular risk prediction beyond SCORE2 in autoimmune rheumatic diseases: a 7-year follow-up study.

RMD open·2026
Same author

Converging metabolic and functional networks for tremor expression and deep brain stimulation-mediated control.

NPJ Parkinson's disease·2026
Same author

Color Doppler carotid resistance, pulsatility, and aortic oscillometry indices in giant cell arteritis: insights from the VASCARD cohort.

Arthritis research & therapy·2026
Same author

The preventive effects of plantago major, mallow and Honey on radiation-induced dermatitis in patients with breast cancer: A double-blind clinical trial.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same author

Macroscale Gradient-Informed Neural Oscillation Topography in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2026

Related Experiment Video

Updated: May 27, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.2K

Navigating neural pathways: how stimulation polarity shapes deep brain stimulation efficacy.

Atefeh Asadi1, Nabin Koirala2,3,4, Muthuraman Muthuraman1,5

  • 1Department of Neurology, University Hospital Würzburg, Würzburg 97080, Germany.

Brain Communications
|February 21, 2025
PubMed
Summary

This study highlights how electrical stimulation polarity influences neural pathway activation in the subthalamic region. Understanding this relationship is crucial for developing effective neuromodulation therapies.

More Related Videos

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

8.8K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

20.1K

Related Experiment Videos

Last Updated: May 27, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

22.2K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

8.8K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

20.1K

Area of Science:

  • Neuroscience
  • Neuromodulation
  • Brain-Computer Interfaces

Background:

  • The subthalamic region plays a key role in motor control and is a target for deep brain stimulation (DBS).
  • The precise mechanisms by which electrical stimulation activates neural pathways in this region remain incompletely understood.
  • Stimulation polarity is a fundamental parameter in electrical neurostimulation.

Purpose of the Study:

  • To comment on the findings by Borgheai et al. regarding neural pathway activation in the subthalamic region.
  • To emphasize the critical role of stimulation polarity in modulating neural activity.
  • To discuss the implications for optimizing neuromodulation strategies.

Main Methods:

  • This is a scientific commentary, not an original research study.
  • It analyzes and discusses the experimental findings presented by Borgheai et al.
  • The commentary likely involves theoretical interpretation of electrophysiological data.

Main Results:

  • Neural pathway activation in the subthalamic region is demonstrably dependent on the polarity of the applied electrical stimulation.
  • Different stimulation polarities can lead to distinct patterns of neural network engagement.
  • This finding underscores the importance of precise parameter control in neuromodulation.

Conclusions:

  • Stimulation polarity is a critical determinant of efficacy and specificity in targeting neural circuits within the subthalamic nucleus.
  • Future neuromodulation approaches should carefully consider and optimize stimulation polarity.
  • This work contributes to a deeper understanding of subthalamic nucleus function and stimulation.