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Treatment of Chronic-Relapsing Pitted Keratolysis with Glycopyrronium Bromide Cream: Case Report

Stefano Veraldi1, Rossana Schianchi2, Italo Francesco Aromolo3

  • 1Dermatological Centre in Milan, Milan, Italy.

Case Reports in Dermatology
|February 21, 2025
PubMed
Abstract

Insights

Pitted keratolysis (PK), a foot infection causing pits and odor, often recurs. A new topical glycopyrronium bromide cream effectively treated two patients, suggesting its use for preventing recurrent PK.

Area of Science:

  • Dermatology
  • Microbiology
  • Pharmacology

Background:

  • Pitted keratolysis (PK) is a superficial bacterial infection of the soles, frequently linked to hyperhidrosis (excessive sweating).
  • Clinical presentation includes characteristic crateriform pits, maceration, and malodor.
  • Current therapeutic options for PK are often unsatisfactory, especially for chronic or relapsing cases.

Observation:

  • Two patients with chronic-relapsing PK were treated.
  • Treatment involved a cream containing 1% glycopyrronium bromide.

Findings:

  • The topical glycopyrronium bromide cream demonstrated successful treatment outcomes in both patients.
  • Glycopyrronium bromide acts as a topical anticholinergic, specifically targeting hyperhidrosis.

Implications:

  • Topical glycopyrronium bromide cream shows promise as a preventative strategy for chronic-relapsing PK.
  • This treatment offers a potential new therapeutic avenue for managing PK by addressing the underlying hyperhidrosis.
  • Further research with larger patient cohorts is warranted to confirm efficacy and safety.
Keywords:
Case reportGlycopyrronium bromideHyperhidrosisPitted keratolysisTopical cholinergics

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