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Hyperthyroidism-Induced Nondiabetic Ketoacidosis: A Rare Case Report
Elias Battikh1, Sherif Mostafa1, Hadeel Alfar2
1Department of Internal Medicine Hamad Medical Corporation Doha Qatar.
Clinical Case Reports
|February 21, 2025
Summary
This case report highlights hyperthyroidism as a rare cause of nondiabetic ketoacidosis (NDKA). Early diagnosis and treatment of hyperthyroidism are crucial for resolving NDKA symptoms.
Area of Science:
- Endocrinology
- Metabolic Disorders
Background:
- Hyperthyroidism involves excess thyroid hormones (T4, T3), causing symptoms like palpitations and weight loss.
- Nondiabetic ketoacidosis (NDKA) is a rare complication of hyperthyroidism, linked to increased lipolysis and ketogenesis.
Purpose of the Study:
- To report a case of hyperthyroidism-induced NDKA in a 40-year-old woman.
- To emphasize the importance of considering hyperthyroidism in NDKA differential diagnoses.
Main Methods:
- Case presentation of a 40-year-old woman with symptoms of hyperthyroidism and NDKA.
- Laboratory evaluation including thyroid function tests (TSH, free T4, T3) and metabolic panel (ketones, anion gap).
Main Results:
- The patient presented with hyperthyroid symptoms and laboratory findings of suppressed TSH, elevated free T4/T3, and NDKA.
- Treatment with propranolol and carbimazole led to significant symptom improvement and biochemical normalization.
Conclusions:
- Hyperthyroidism is an uncommon but important cause of NDKA that should be considered when other causes are ruled out.
- Prompt diagnosis and management of hyperthyroidism with antithyroid medications are effective in resolving NDKA.
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