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Updated: May 27, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Simple synthesis of 2-(phenylsulphinyl)benzo[d]oxazole derivatives via a silver-catalysed tandem condensation
Runsheng Xu1, Qi Hu1, Jiahao Hu1
1College of Life and Health, Huzhou College Huzhou Zhejiang 211300 China xurunsheng@zjhzu.edu.cn xujin@zjhzu.edu.cn.
Abstract:
Silver catalysed reactions have become an indispensable tool in organic synthesis due to their high efficiency, selectivity, and environmental friendliness. In this manuscript, the simple synthesis reaction generating 2-(phenylsulphinyl)benzo[d]oxazole derivatives via a silver-catalysed tandem condensation reaction is described. Starting from substituted 2-aminophenols or benzene-1,2-diamines, formaldehyde with substituted benzenethiols efficiently yields versatile biologically active 2-(phenylsulphinyl)benzo[d]oxazole derivatives and 2-(phenylsulphinyl)-1H-benzo[d]imidazole derivatives. These protocols were performed under mild reaction conditions, tested for wider substrate scope, and provide an economical approach for C(sp2)-sulphoxide bond formation.
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