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Addressing challenges in pediatric thrombosis: a comprehensive guideline development.
Yin Wang1, Qinan Yin1, Jiangting Liao1
1Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Frontiers in Pediatrics
|February 21, 2025
Summary
This study developed a guideline for pediatric thrombosis pharmacotherapy. It provides evidence-based recommendations for anticoagulant medications to improve treatment and prevention in children.
Area of Science:
- Pediatric Hematology
- Pharmacology
- Evidence-Based Medicine
Background:
- Pediatric thrombosis is a severe condition with increasing incidence.
- Children's unique physiology necessitates distinct treatment guidelines from adults.
- Current pharmacological management of pediatric thrombosis presents significant challenges.
Purpose of the Study:
- To conduct a systematic review of evidence-based literature for pediatric thrombosis.
- To propose pharmacological prevention and treatment recommendations for pediatric thrombotic diseases.
- To develop a practical pharmacotherapy guideline for rational medication use in children.
Main Methods:
- Followed WHO Handbook for Guideline Development, including systematic literature searches.
- Utilized the Delphi method for expert consensus on clinical issues and recommendations.
- Employed the GRADE approach to assess the quality of evidence.
Main Results:
- Collected and evaluated 29 clinical issues with 78 experts.
- Selected 13 key clinical issues through two Delphi rounds.
- Formulated 13 clinical pharmacotherapy recommendations for pediatric thrombosis.
Conclusions:
- Developed a guideline with specific anticoagulant recommendations for pediatric thrombosis.
- Aims to enhance the feasibility, safety, and standardization of pediatric thrombosis treatment.
- Promotes more effective prevention and management strategies for pediatric thrombotic diseases.
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