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Addressing challenges in pediatric thrombosis: a comprehensive guideline development

Yin Wang1, Qinan Yin1, Jiangting Liao1

  • 1Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Pediatrics
|February 21, 2025
PubMed

Insights

This study developed a guideline for pediatric thrombosis pharmacotherapy. It provides evidence-based recommendations for anticoagulant medications to improve treatment and prevention in children.

Area of Science:

  • Pediatric Hematology
  • Pharmacology
  • Evidence-Based Medicine

Background:

  • Pediatric thrombosis is a severe condition with increasing incidence.
  • Children's unique physiology necessitates distinct treatment guidelines from adults.
  • Current pharmacological management of pediatric thrombosis presents significant challenges.

Purpose of the Study:

  • To conduct a systematic review of evidence-based literature for pediatric thrombosis.
  • To propose pharmacological prevention and treatment recommendations for pediatric thrombotic diseases.
  • To develop a practical pharmacotherapy guideline for rational medication use in children.

Main Methods:

  • Followed WHO Handbook for Guideline Development, including systematic literature searches.
  • Utilized the Delphi method for expert consensus on clinical issues and recommendations.
  • Employed the GRADE approach to assess the quality of evidence.

Main Results:

  • Collected and evaluated 29 clinical issues with 78 experts.
  • Selected 13 key clinical issues through two Delphi rounds.
  • Formulated 13 clinical pharmacotherapy recommendations for pediatric thrombosis.

Conclusions:

  • Developed a guideline with specific anticoagulant recommendations for pediatric thrombosis.
  • Aims to enhance the feasibility, safety, and standardization of pediatric thrombosis treatment.
  • Promotes more effective prevention and management strategies for pediatric thrombotic diseases.
Abstract

Keywords:
anticoagulationpediatric thrombosispharmaceutical practice guidelinerational drug usethrombosis prevention and treatment

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