Assessment of Renal Function in Patients with Chronic Kidney Disease with and without Hypothyroidism

Area of Science:

• Endocrinology
• Nephrology

Background:

• Hypothyroidism is a common endocrine disorder with a known bidirectional relationship with Chronic Kidney Disease (CKD).
• Hypothyroidism presents a significant complication for individuals already diagnosed with CKD.
• The interplay between these two conditions necessitates further investigation into their impact on kidney function.

Purpose of the Study:

• To investigate the impact of hypothyroidism on the progression of kidney dysfunction in patients with Chronic Kidney Disease.
• To compare kidney function markers between CKD patients with and without hypothyroidism.

Main Methods:

• A cohort of 150 participants, including 110 CKD patients without hypothyroidism and 40 CKD patients with hypothyroidism, was studied.
• Participants were stratified into CKD stages 3, 4, and 5 based on estimated Glomerular Filtration Rate (eGFR).
• Key clinical and demographic data, including serum creatinine, urea, BUN, eGFR, and electrolytes, were monitored over a three-month period.

Main Results:

• CKD patients with hypothyroidism exhibited significantly higher serum creatinine, urea, and Blood Urea Nitrogen (BUN) levels compared to those without hypothyroidism.
• A significantly lower estimated Glomerular Filtration Rate (eGFR) was observed in CKD patients with hypothyroidism (P < 0.0001).
• Elevated potassium levels were noted in the hypothyroidism group (P = 0.0001), while sodium and chloride levels showed no significant differences.

Conclusions:

• Hypothyroidism is associated with a more pronounced decline in kidney function among Chronic Kidney Disease patients.
• The findings highlight the critical impact of thyroid status on renal health in the context of CKD.
• Management of hypothyroidism may be crucial for preserving kidney function in CKD patients.