Related Experiment Video
Updated: May 6, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Serendipitous Discovery of Lipemia Retinalis in a Premature Infant: A Case Report
Homayoun Nikkhah1,2,3, Narges Karrabi1,2,3, Ehsan Yazdani1,2,3
1Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Lipemia retinalis (LR), a rare condition of creamy retinal vessels due to high triglycerides, was identified in a preterm infant. Dietary management led to resolution, highlighting early detection
Area of Science:
- Ophthalmology
- Pediatrics
- Metabolic Disorders
Background:
- Lipemia retinalis (LR) presents as creamy white retinal vessels, indicating severe hypertriglyceridemia.
- Pediatric populations, especially preterm infants, are susceptible to metabolic disorders like LR.
Introduction:
Lipemia retinalis (LR) is a rare ocular condition characterized by a creamy white appearance of the retinal vessels, which is indicative of significantly elevated serum triglyceride (TG) levels. This condition is particularly noteworthy in pediatric populations, especially in preterm infants who are at risk for various metabolic disorders.
Case Presentation:
We report a case of LR in a 44-day-old preterm infant identified during routine retinopathy of prematurity (ROP) screening. Unusual retinal findings led to metabolic investigations, revealing elevated TG levels confirming LR. The infant was managed with a dietary regimen including skimmed milk, resulting in a substantial decrease in TG levels and complete resolution of the retinal changes.
Conclusion:
Fundus examination serves as a portal to the systemic health of an individual, enabling rare identification of LR, indicative of underlying dyslipidemia. This case underscores the necessity for comprehensive metabolic screening in preterm infants, particularly during ROP assessments. Furthermore, it emphasizes the effectiveness of dietary interventions in managing LR. The favorable outcomes stress the significance of early detection of LR in pediatric patients and implementing nutritional strategies to enhance metabolic well-being, thereby averting severe hypertriglyceridemia complications.

