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Stability of metronidazole and ten antibiotics when mixed with magnesium sulphate solutions
Abstract:
The chemical stabilities of metronidazole (in water) and ten antibiotics (ampicillin, carbenicillin, cefamandole, cefazolin, cefoxitin, moxalactam, nafcillin, penicillin G, piperacillin, and ticarcillin) in 5% dextrose injection (except ampicillin which was in 0.9% sodium chloride) with magnesium sulphate were studied at 25 degrees C. The clarity of the solutions did not change in 20 h. The pH values of metronidazole, nafcillin and penicillin G solutions containing magnesium sulphate were lower (at 0 and 20 h) by up to 1.2 units as compared with solutions without magnesium sulphate. The decomposition of nafcillin and penicillin G solutions was hastened significantly by magnesium sulphate due to effect on the pH values of the solutions.
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