Related Experiment Video
Updated: May 26, 2025
08:30
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
1.8K
Tissue-Resident Th2 Cells in Type 2 Immunity and Allergic Diseases.
Jenny M Mannion1,2, Rod A Rahimi1,2
1Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Immunological Reviews
|February 21, 2025
Summary
Tissue-resident CD4+ T helper type 2 (Th2) cells are critical in chronic allergic inflammation. New insights reveal checkpoints regulating their development and function, offering therapeutic targets for allergic diseases.
Area of Science:
- Immunology
- Cell Biology
- Allergy Research
Background:
- Type 2 immunity protects against parasites and toxins but can cause allergic diseases when dysregulated.
- Tissue-resident CD4+ T helper type 2 (Th2) cells are increasingly recognized for their role in chronic allergic inflammation.
Purpose of the Study:
- To review current understanding of regulatory checkpoints governing tissue-resident Th2 cell development and function.
- To focus on the role of these cells in chronic allergic diseases.
- To discuss potential therapeutic strategies targeting tissue-resident Th2 cells.
Main Methods:
- Review of recent human and murine studies on Th2 cell biology.
- Analysis of mechanisms controlling Th2 cell differentiation and function in vivo.
- Examination of barrier tissue checkpoints in Th2 cell priming and allergic inflammation.
Main Results:
- Evidence suggests a barrier tissue checkpoint influences initial Th2 cell priming via neuropeptides, DAMPs, and DC macro-clusters.
- A second barrier tissue checkpoint promotes multi-cytokine producing, tissue-resident Th2 cells that drive allergic inflammation.
Conclusions:
- Understanding the checkpoints regulating tissue-resident Th2 cells is crucial for comprehending chronic allergic diseases.
- Targeting these specific checkpoints offers promising therapeutic avenues for allergic conditions.
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