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The key role of miR‑378 in kidney diseases (Review)

Yangyang Liu1, Shuqing Shi2, Tao Cheng2

  • 1Department of Cardiovascular Diseases, Sanming Integrated Medicine Hospital, Sanming, Fujian 365000, P.R. China.

Molecular Medicine Reports
|February 21, 2025
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are crucial for kidney development and function. This review consolidates research on miR-378

Area of Science:

  • Molecular Biology
  • Genetics
  • Nephrology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNA dysregulation is linked to various diseases, including kidney conditions.
  • miRNA expression is vital for kidney development and function.

Purpose of the Study:

  • To consolidate existing literature on the role of miR-378 in kidney diseases.
  • To highlight validated gene targets and biological effects of miR-378.
  • To provide a foundation for future research on miR-378 in renal pathology.

Main Methods:

  • Comprehensive literature review of studies involving miR-378 and kidney diseases.
  • Analysis of validated gene targets associated with miR-378.
  • Synthesis of biological effects of miR-378 in malignant and non-malignant kidney conditions.

Main Results:

  • miR-378 is implicated in pathological processes of kidney diseases such as cancer, transplantation, and diabetic nephropathy.
  • Validated gene targets and specific biological effects of miR-378 in renal cell lineages are identified.
  • The review consolidates diverse roles of miR-378 in kidney disease contexts.

Conclusions:

  • miR-378 plays a significant role in kidney disease pathogenesis.
  • Understanding miR-378's targets and functions is crucial for advancing research in nephrology.
  • This review serves as a foundational resource for exploring miR-378's therapeutic potential in kidney diseases.
Keywords:
gene targetskidney diseasesmiRNAmicroRNA‑378

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