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Updated: Aug 8, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Seventh ISNS Reference Preparation for Neonatal Screening for Thyroid Stimulating Hormone, Phenylalanine, and
Peter C J I Schielen1, Dianne Webster2,3, J Gerard Loeber1
1International Society for Neonatal Screening, Reigerskamp 273, 3607HP Maarssen, The Netherlands.
Abstract:
The International Society for Neonatal Screening (ISNS) has supported the standardization of the measurement of key biochemical markers for the neonatal screening of diseases: thyroid-stimulating hormone (TSH) for congenital hypothyroidism, phenylalanine (PHE) for phenylketonuria, and 17α-hydroxyprogesterone (17OHP) for congenital adrenal hyperplasia. These diseases are commonly a part of neonatal screening panels worldwide. The ISNS provides a series of secondary reference materials to the manufacturers of neonatal screening reagents to assist in the production of calibration materials for kits. This technical note describes the manufacture of the seventh combined dried blood spot reference preparation for neonatal screening (RPNS) for these analytes.

