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Epidemiological Characterization of Uveitis in Japan: a Systematic Review
Tom Liba1, Alon Gorenshtein1,2, Liron Leibovitch1
1Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Ocular Immunology and Inflammation
|February 21, 2025
Summary
Regional variations in uveitis causes exist across Japan, with sarcoidosis being a leading factor. Unclassified uveitis remains common, highlighting the need for improved diagnostic methods.
Area of Science:
- Ophthalmology
- Immunology
- Public Health
Background:
- Uveitis, a group of inflammatory eye conditions, presents diverse etiologies.
- Understanding geographical variations in uveitis causes is crucial for targeted healthcare strategies.
Approach:
- A systematic review adhering to PRISMA guidelines was performed.
- Searched major databases (PubMed/MEDLINE, Scopus, Web of Science) for studies on Japanese uveitis from 1990-2024.
- Included English and Japanese studies reporting uveitis etiologies, excluding self-reported data.
Key Points:
- Twenty studies met inclusion criteria from 1,738 initial records.
- Sarcoidosis, Vogt-Koyanagi-Harada (VKH) disease, and Behcet's disease were common systemic causes.
- Significant regional differences observed, e.g., sarcoidosis prevalence in Hokkaido (19.5%) vs. Tokyo (8.9%).
Conclusions:
- Uveitis etiologies demonstrate significant regional variation within Japan.
- Sarcoidosis is a major contributor to uveitis, with prevalence differing by region.
- High rates of unclassified uveitis necessitate enhanced diagnostic approaches.
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