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Factors associated with CIN2-3 recurrence: A single center retrospective analysis
Zhuo-Yi Li1, Kai Wang2, Xiao-Ling Shen1
1Women's Health Care Department, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen City, Fujian Province, China.
Human Vaccines & Immunotherapeutics
|February 21, 2025
Summary
Recurrence of cervical intraepithelial neoplasia grade 2-3 (CIN2-3) is influenced by HPV genotype and margin status. Adjuvant HPV vaccination and prior cytology are key factors in preventing CIN2-3 relapse.
Area of Science:
- Gynecology
- Oncology
- Virology
Background:
- Cervical intraepithelial neoplasia grade 2-3 (CIN2-3), a high-grade squamous intraepithelial lesion (HSIL), carries a significant risk of recurrence and progression to cervical cancer.
- Predictive factors for CIN2-3 recurrence remain incompletely understood, necessitating further investigation.
Purpose of the Study:
- To identify independent risk factors influencing the recurrence of cervical intraepithelial neoplasia grade 2-3 (CIN2-3) after treatment.
- To clarify the role of human papillomavirus (HPV) status, treatment margins, and HPV vaccination in disease recurrence.
Main Methods:
- A retrospective cohort study involving 142 patients diagnosed with CIN2-3, treated for lesion removal, and followed for at least two years.
- Statistical analyses included Fisher's exact test, Pearson's chi-squared test, Kruskal-Wallis test for univariate analysis, and logistic regression for identifying independent risk factors.
Main Results:
- HPV genotype before treatment (P=0.003) and positive margin status (P=0.031) were significantly associated with post-treatment cervical lesion status.
- Cytology results before treatment (OR=0.634) and HPV vaccination (OR=0.340) were identified as independent protective factors against CIN2-3 recurrence within two years.
Conclusions:
- This study highlights HPV genotype and margin status as critical factors in CIN2-3 recurrence.
- Adjuvant HPV vaccination emerges as a significant independent factor in preventing recurrence, suggesting its potential role in managing women with cervical preinvasive disease.
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