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Updated: May 26, 2025

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
Published on: December 6, 2024
[Optimized interaction with Large Language Models : A practical guide to Prompt Engineering and Retrieval-Augmented
Anna Fink1,2, Alexander Rau3, Elmar Kotter4
1Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Freiburg, Medizinische Fakultät der Universität Freiburg, Freiburg, Deutschland. anna.fink@uniklinik-freiburg.de.
Background:
Given the increasing number of radiological examinations, large language models (LLMs) offer promising support in radiology. Optimized interaction is essential to ensure reliable results.
Objectives:
This article provides an overview of interaction techniques such as prompt engineering, zero-shot learning, and retrieval-augmented generation (RAG) and gives practical tips for their application in radiology.
Materials And Methods:
Demonstration of interaction techniques based on practical examples with concrete recommendations for their application in routine radiological practice.
Results:
Advanced interaction techniques allow task-specific adaptation of LLMs without the need for retraining. The creation of precise prompts and the use of zero-shot and few-shot learning can significantly improve response quality. RAG enables the integration of current and domain-specific information into LLM tools, increasing the accuracy and relevance of the generated content.
Conclusions:
The use of prompt engineering, zero-shot and few-shot learning, and RAG can optimize interaction with LLMs in radiology. Through these targeted strategies, radiologists can efficiently integrate general chatbots into routine practice to improve patient care.
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