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Related Concept Videos

Rapid Identification of Pathogens01:25

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

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Real-world clinical evaluation of the Inflammatix TriVerity test for sepsis at the emergency department: an Acutelines study.

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Related Experiment Video

Updated: Jun 7, 2026

A Rapid, Multiplex Dual Reporter IgG and IgM SARS-CoV-2 Neutralization Assay for a Multiplexed Bead-Based Flow Analysis System
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Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test.

Jingyi Lu1, Michèle A Ter Voert2, Mehtap Ünal1,2

  • 1Department of Internal Medicine, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

Intensive Care Medicine Experimental
|February 21, 2025
PubMed
Summary

The TriVerity™ Test rapidly identifies bacterial and viral infections in emergency departments. This host-response mRNA test aids clinical decisions by assessing infection likelihood and illness severity.

Keywords:
Acute infectionAcutelinesDiagnosisHost responsePrognosisSepsisTriVeritymRNA

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Area of Science:

  • Medical Diagnostics
  • Infectious Diseases
  • Molecular Diagnostics

Background:

  • Early sepsis diagnosis is critical for effective treatment.
  • The TriVerity™ Test is a novel, rapid, multiplex host-response mRNA diagnostic.
  • It aids clinical decision-making for bacterial/viral infections and illness severity.

Purpose of the Study:

  • To evaluate the real-world performance of the TriVerity™ Test in an emergency department.
  • To assess its ability to differentiate bacterial and viral infections.
  • To determine its utility in assessing illness severity.

Main Methods:

  • Collected blood samples from adult patients with suspected infections in the ED.
  • Performed TriVerity™ Test using LAMP technology on the Myrna™ Instrument within 1 hour.
  • Adjudicated infection status via post hoc chart review.

Main Results:

  • Bacterial infection results showed 95% rule-in specificity and 95% rule-out sensitivity.
  • Viral infection results demonstrated 100% rule-in specificity and 92% rule-out sensitivity.
  • Limited data on severe outcomes due to small patient cohort.

Conclusions:

  • TriVerity™ is a rapid, whole-blood test for detecting bacterial/viral infections and assessing illness severity in ED patients.
  • Its fast turnaround time supports ED workflow and timely clinical decisions.
  • Larger validation studies are needed for detailed diagnostic and prognostic accuracy.