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Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test.
Jingyi Lu1, Michèle A Ter Voert2, Mehtap Ünal1,2
1Department of Internal Medicine, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.
Intensive Care Medicine Experimental
|February 21, 2025
Summary
The TriVerity™ Test rapidly identifies bacterial and viral infections in emergency departments. This host-response mRNA test aids clinical decisions by assessing infection likelihood and illness severity.
Area of Science:
- Medical Diagnostics
- Infectious Diseases
- Molecular Diagnostics
Background:
- Early sepsis diagnosis is critical for effective treatment.
- The TriVerity™ Test is a novel, rapid, multiplex host-response mRNA diagnostic.
- It aids clinical decision-making for bacterial/viral infections and illness severity.
Purpose of the Study:
- To evaluate the real-world performance of the TriVerity™ Test in an emergency department.
- To assess its ability to differentiate bacterial and viral infections.
- To determine its utility in assessing illness severity.
Main Methods:
- Collected blood samples from adult patients with suspected infections in the ED.
- Performed TriVerity™ Test using LAMP technology on the Myrna™ Instrument within 1 hour.
- Adjudicated infection status via post hoc chart review.
Main Results:
- Bacterial infection results showed 95% rule-in specificity and 95% rule-out sensitivity.
- Viral infection results demonstrated 100% rule-in specificity and 92% rule-out sensitivity.
- Limited data on severe outcomes due to small patient cohort.
Conclusions:
- TriVerity™ is a rapid, whole-blood test for detecting bacterial/viral infections and assessing illness severity in ED patients.
- Its fast turnaround time supports ED workflow and timely clinical decisions.
- Larger validation studies are needed for detailed diagnostic and prognostic accuracy.
