Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal dynamics and regional disparities in HIV/AIDS and extensively drug-resistant tuberculosis mortality in South Asia: A systemic analysis of global burden of disease data (1993-2021).

The Indian journal of tuberculosis·2026
Same author

Effectiveness of vericiguat in heart failure across ejection fraction phenotypes: a comprehensive meta-analytic trial sequential analysis and meta-regression analysis.

Annals of medicine and surgery (2012)·2026
Same author

Linking chemical data from the Comparative Toxicogenomics Database with adverse outcome pathways from the AOP-Wiki: a mechanistic data-oriented approach to help inform environmental health.

F1000Research·2026
Same author

Comparative effectiveness of cholesteryl ester transfer protein (CETP) inhibitors on cardiovascular outcomes: A comprehensive Bayesian network meta-analysis and network meta-regression.

Medicine·2026
Same author

Unraveling the Complexities of Kartagener's Syndrome: A Case of Bronchiectasis, Isolated Dextrocardia, and Primary Ciliary Dyskinesia in an Adult With Chronic Respiratory Symptoms.

Clinical case reports·2026
Same author

Epidemiologic trajectories and burden of multidrug-resistant tuberculosis (MDR-TB) mortality across South Asia: An analysis of Global Burden of Disease data (1990-2023) with machine learning forecasting to 2050.

Journal of clinical tuberculosis and other mycobacterial diseases·2026

Related Experiment Video

Updated: Jul 7, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.2K

Integrating AI-powered text mining from PubTator into the manual curation workflow at the Comparative Toxicogenomics

Thomas C Wiegers1, Allan Peter Davis1, Jolene Wiegers1

  • 1Department of Biological Sciences, North Carolina State University, Toxicology Building, 850 Main Campus Drive, Raleigh, NC 27695, USA.

Database : the Journal of Biological Databases and Curation
|February 21, 2025
PubMed
Summary

The Comparative Toxicogenomics Database (CTD) now uses PubTator 3.0, an AI tool, to speed up the curation of scientific literature on environmental exposures and human health. This integration enhances the efficiency of linking chemicals, genes, diseases, and phenotypes.

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

8.8K
Automated Dissection Protocol for Tumor Enrichment in Low Tumor Content Tissues
06:44

Automated Dissection Protocol for Tumor Enrichment in Low Tumor Content Tissues

Published on: March 29, 2021

2.5K

Related Experiment Videos

Last Updated: Jul 7, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.2K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

8.8K
Automated Dissection Protocol for Tumor Enrichment in Low Tumor Content Tissues
06:44

Automated Dissection Protocol for Tumor Enrichment in Low Tumor Content Tissues

Published on: March 29, 2021

2.5K

Area of Science:

  • Toxicogenomics
  • Bioinformatics
  • Computational Biology

Background:

  • The Comparative Toxicogenomics Database (CTD) manually curates literature to understand environmental exposures and human health.
  • CTD organizes molecular relationships between chemicals, genes, phenotypes, diseases, and species using ontologies and controlled vocabularies.
  • Manual text normalization for curation is time-consuming.

Purpose of the Study:

  • To improve the efficiency of CTD's literature curation process.
  • To evaluate and integrate PubTator 3.0, an AI-powered resource, into CTD's workflow.
  • To leverage Natural Language Processing (NLP) for faster data extraction and normalization.

Main Methods:

  • CTD evaluated PubTator 3.0's capabilities against its specific curation objectives.
  • PubTator 3.0 was integrated into CTD's existing curation workflow.
  • The study describes CTD's history with NLP and its strategy for NLP integration.

Main Results:

  • PubTator 3.0 successfully extracts and normalizes key biomedical concepts relevant to CTD's curation needs.
  • The integration of PubTator 3.0 is expected to significantly improve the efficiency of CTD's biocurators.
  • This AI-powered approach facilitates faster hypothesis generation regarding environmental health impacts.

Conclusions:

  • Integrating AI tools like PubTator 3.0 enhances the efficiency of large-scale biological databases.
  • Streamlined curation processes accelerate scientific discovery in toxicogenomics.
  • CTD's adoption of NLP demonstrates a commitment to advancing human health research through efficient data management.