SCF^RMF-dependent degradation of the nuclear lamina releases the somatic chromatin mobility restriction for meiotic...

Meiosis prepares the genome for sexual reproduction and is a driver of genetic diversity. Essential for both aspects are rapid chromosome movements enabling the pairing of homologous chromosomes, thereby promoting their recombination and ensuring their correct segregation afterward. However, it is unknown how meiocytes reorganize their nuclear architecture when chromosomes are tethered to the nuclear lamina in somatic cells. Here, we reveal the meiosis-specific Skp1-Cul1-F-box-protein (SCF) E3 ubiquitin ligase SCF^RMF as a key regulator of this reorganization in Arabidopsis. We find that the nuclear lamina proteins of the CRWN family are degraded in an SCF^RMF-dependent manner in this process. Thus, the SCF^RMF functions to release the somatic constraints on chromosome mobility through disrupting the nuclear lamina, allowing homologous chromosomes to pair.